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Methods Here we investigated the microbial and molecular composition of CF sputum samples using 16S rRNA gene amplicon sequencing and untargeted tandem mass spectrometry to determine their interrelationships and associations with clinical measures of disease severity. Results The CF metabolome was found to exist in two states: one from patients with more severe disease that had higher molecular diversity and more Pseudomonas aeruginosa and the other from patients with better lung function having lower metabolite diversity and fewer pathogenic bacteria. The two molecular states were differentiated by the abundance and diversity of peptides and amino acids. Patients with severe disease and more pathogenic bacteria had higher levels of peptides.

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The Man from U. Indira Gandhi : Archer states that his shirt smells like the former prime minister of India's thong. Keebler Elves : Archer mentioning that his brain is like a tree and Lana is the little cookie elves. Brian's Song : Archer suggests that he helped a guy with cancer, as in the movie about a football player stricken with terminal cancer and his friendship with his teammate.

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International obligations[ edit ] Neither the European Union nor the Council of Europe have suggested any specific age of consent, and there has not been any effort so far to standardize the age across member states. However, most countries in Europe now have binding legal obligations in regard to the sexual abuse of children under

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